BRCA1
BReast CAncer gene 1 · Chromosome 17q21.31
A BRCA1 mutation significantly raises breast and ovarian cancer risk. Learn about risk levels, testing criteria, screening, and next steps.
- Female breast cancer
- Ovarian cancer
- Pancreatic cancer
Gene Guides
Comprehensive, medically reviewed guides on hereditary cancer genes. Understand your risk, testing options, and what to do if you carry a mutation.
BRCA-Related Genes
Genes involved in the BRCA DNA repair pathway, associated with breast, ovarian, and other cancers.
BRCA2
BReast CAncer gene 2 · Chromosome 13q13.1
A BRCA2 mutation raises breast, ovarian, pancreatic, and prostate cancer risk. Learn about risk levels, screening, and what to do next.
- Female breast cancer
- Ovarian cancer
- Male breast cancer
PALB2
Partner and Localizer of BRCA2 · Chromosome 16p12.2
A PALB2 mutation significantly raises breast and pancreatic cancer risk. Learn about risk levels, testing criteria, and recommended screening.
- Female breast cancer
- Pancreatic cancer
- Ovarian cancer
ATM
Ataxia-Telangiectasia Mutated · Chromosome 11q22.3
An ATM gene mutation raises breast, ovarian, and pancreatic cancer risk. Learn about risk levels, who should test, and recommended screening.
- Female breast cancer
- Pancreatic cancer
- Ovarian cancer
CHEK2
Checkpoint Kinase 2 · Chromosome 22q12.1
A CHEK2 mutation raises breast and colon cancer risk. Learn what the research says about risk levels, recommended screening, and what to do next.
- Female breast cancer
- Colorectal cancer
- Prostate cancer
Lynch Syndrome Genes
Mismatch repair genes associated with Lynch syndrome, the most common hereditary cancer predisposition.
MLH1
MutL Homolog 1 · Chromosome 3p21.3
Understand the MLH1 gene, its central role in Lynch syndrome, colorectal and endometrial cancer risk statistics, testing guidelines, and management options.
- Colorectal cancer
- Endometrial cancer
- Ovarian cancer
MSH2
MutS Homolog 2 · Chromosome 2p21-p16.3
MSH2 mutations cause Lynch syndrome, raising colon, uterine, and ovarian cancer risk. Learn about screening and what Lynch syndrome carriers need.
- Colorectal cancer
- Endometrial cancer
- Ovarian cancer
Other Hereditary Cancer Genes
Genes associated with rare but highly actionable hereditary cancer syndromes.
TP53
Tumor Protein p53 · Chromosome 17p13.1
Learn about the TP53 gene, its role in Li-Fraumeni syndrome, the wide spectrum of associated cancers, lifetime risk statistics, and management strategies for carriers.
- Breast cancer
- Soft tissue sarcoma
- Osteosarcoma
CDH1
Cadherin 1 (E-cadherin) · Chromosome 16q22.1
Understand the CDH1 gene, its role in hereditary diffuse gastric cancer and lobular breast cancer, risk statistics, testing guidelines, and management options.
- Diffuse gastric cancer
- Lobular breast cancer
- Colorectal cancer
PTEN
Phosphatase and Tensin Homolog · Chromosome 10q23.31
Learn about the PTEN gene, its role in Cowden syndrome, breast, thyroid, and endometrial cancer risk statistics, testing recommendations, and management strategies.
- Female breast cancer
- Thyroid cancer
- Endometrial cancer
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